Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines.

نویسندگان

  • W J Britton
  • E Martin
  • A T Kamath
  • K D Neupane
  • P W Roche
چکیده

We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.

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عنوان ژورنال:
  • Leprosy review

دوره 71 Suppl  شماره 

صفحات  -

تاریخ انتشار 2000